scholarly journals A multivariate analysis of blood vessel and lymph vessel invasion as predictors of ovarian and lymph node metastases in patients with cervical carcinoma

Cancer ◽  
2000 ◽  
Vol 88 (11) ◽  
pp. 2578-2583 ◽  
Author(s):  
Noriaki Sakuragi ◽  
Naoki Takeda ◽  
Hitoshi Hareyama ◽  
Toshio Fujimoto ◽  
Yukiharu Todo ◽  
...  
Keyword(s):  
Multivariate Analysis ◽  
Lymph Node ◽  
Blood Vessel ◽  
Cervical Carcinoma ◽  
Lymph Node Metastases ◽  
Lymph Vessel ◽  
Lymph Vessel Invasion ◽  
Vessel Invasion ◽  
Node Metastases

Multivariate analysis of prognostic factors among 706 mucosal melanoma patients.

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. 9569-9569
Author(s):  
Bin Lian ◽  
Chuanliang Cui ◽  
Li Zhou ◽  
Xin Song ◽  
Xiaoshi Zhang ◽  
...  
Keyword(s):  
Multivariate Analysis ◽  
Prognostic Factors ◽  
Lymph Node ◽  
Survival Rate ◽  
Lymph Node Metastases ◽  
Distant Metastases ◽  
Mucosal Melanoma ◽  
Depth Of Invasion ◽  
Prognostic Analysis ◽  
Node Metastases

9569 Background: Mucosal melanoma is rare and associated with extremely poor prognosis. Little is known about its outcome and prognostic analysis. In this study, we evaluated prognostic factors among mucosal melanomas. Methods: The survival rates, Relapse Free Survival (RFS), Overall Survival (OS) and prognostic factors were compared for 706 mucosal melanomas at different anatomical sites. Results: Mucosal melanoma from nasal pharyngeal and oral (268 pts), upper and lower gastrointestinal (GI) (221 pts), gynecological and urological (196 pts) had a similar survival with a 1-y survival rate (88%, 83%, 86%), 2-y survival rate (66%, 57%, 61%), 5-y survival rate (27%, 16%, 20%), respectively. Multivariate analysis revealed that Depth of Invasion (p < 0.001), Lymph node metastases (p < 0.001), Distant metastases (p < 0.001) were three independent prognostic factors for OS among 706 pts. Anatomical site (p = 0.031), Depth of Invasion (p < 0.001), Lymph node metastases (p < 0.001) were three independent prognostic factors for RFS among 543 pts. KPS status, Depth of Invasion, Lymph node metastases, Distant metastases were independent factors for OS among nasal pharyngeal and oral pts. Depth of Invasion, Lymph node metastases, CKIT Mutation were independent factors for RFS among nasal pharyngeal and oral pts. Gender, Lymph node metastases, Distant metastases were independent factors for OS among GI pts. Gender, Depth of Invasion, Lymph node metastases were independent factors for RFS among GI pts. Lymph node metastases, Distant metastases were independent factors for OS among Gynecological and Urological pts. Depth of Invasion, Lymph node metastases were independent factors for RFS among Gynecological and Urological pts. Conclusions: This is the first prognostic analysis for mucosal melanoma with the largest sample size for the first time. with few exceptions, It revealed that Depth of Invasion, Lymph node metastases, Distant metastases were independent prognostic factors for OS, Depth of Invasion and Lymph node metastases were independent prognostic factors for RFS. These results should be incorporated into the establishment of stage system and design of future clinical trials involving patients with mucosal melanoma.

Radiological evaluation of parametrial invasion and lymph node metastases in patients with cervical carcinoma: a systematic review

2001 ◽  
Vol 1 (S3) ◽  
Author(s):  
Shandra Bipat ◽  
Afina Glas ◽  
Jacobus van der Velden ◽  
Patrick Bossuyt ◽  
Johan Laméris ◽  
...  
Keyword(s):  
Systematic Review ◽  
Lymph Node ◽  
Cervical Carcinoma ◽  
Lymph Node Metastases ◽  
Radiological Evaluation ◽  
Parametrial Invasion ◽  
Node Metastases

scholarly journals Clinical significance of proliferation index and E-cadherin expression in colorectal adenocarcinoma

2021 ◽  
pp. 55-55
Author(s):  
Janko Zujovic ◽  
Milena Vuletic ◽  
Miroslav Stojanovic ◽  
Ranko Lazovic ◽  
Nebojsa Djordjevic ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Lymph Node ◽  
Blood Vessel ◽  
Lymph Node Metastases ◽  
Perineural Invasion ◽  
Distant Metastases ◽  
Proliferation Index ◽  
Blood Vessel Invasion ◽  
Node Metastases ◽  
E Cadherin

Introduction/Objective. The aim of this study is to examine the association of E-cadherin expression and high proliferation index (proIDX) with clinical and pathological indicators of colorectal cancer progression. Methods. The biopsy of 72 patients, obtained by resection of colorectal cancer, was routinely processed at the Institute of Pathology of the Clinical Centre of Montenegro, embedded in paraffin and archived. Based on the archived pathohistological reports, two study groups were formed: the first group (n = 72) consisted of operative biopsies of colorectal cancer, and the control group (n = 72) consisted of biopsies of adjacent non-tumor tissue. Routine hematoxylin-eosin and immunohistochemical ABC method with anti-Ki67 and anti-E-cadherin antibodies was applied on. After quantification of the results for statistical tests, the software package SPSS for Windows (19.0) was used. Results. In colorectal carcinoma, we observed a significant association of proIDX with pT stage, lymph and blood vessel invasion, perineural invasion, lymph node metastases and distant metastases, and Astler-Coller stage tumor disease. We also observed that the absence of E-cadherin was significantly associated with pT stage, lymph and blood vessel invasion, perineural invasion with lymph node metastases, distant metastases, with C2 and D Astler-Coller tumor stage. E-cadherin expression is associated with proIDX with a significantly high, negative correlation coefficient. Conclusion. Our results indicate that it is possible to differentiate patients into groups with a higher or lower risk of developing metastatic disease, based on the expression of Ki67 and E-cadherin.

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